Ruud van Nistelrooy will return to Old Trafford with Leicester City, who were drawn to play former side Manchester United in the FA Cup fourth round.
The Dutchman won the FA Cup with United in 2004, while he briefly served as the Red Devils’ interim boss following Erik ten Hag’s departure earlier this season, before taking over the Foxes.
Ruben Amorim’s United began their title defence with a dramatic victory over Arsenal on penalties at the Emirates Stadium on Sunday, despite playing over an hour with 10 men after Diogo Dalot’s red card.
Elsewhere, Championship bottom club Plymouth Argyle’s reward for stunning Brentford in round three is a home tie against Premier League leaders Liverpool.
Manchester City have been handed an away tie against either Leyton Orient or Derby County, while in-form Nottingham Forest and Newcastle United travel to Exeter City and Birmingham City respectively.
A couple of eye-catching Premier League ties see Aston Villa welcome Tottenham and Brighton host Chelsea, with Everton and Bournemouth also going head-to-head.
Ipswich Town and Wolves travel to Championship opposition in Coventry City and Blackburn Rovers, with Fulham being handed an away tie against either Mansfield Town or Wigan Athletic.
FA Cup fourth-round draw in full
Manchester United v Leicester City
Leeds United v Millwall or Dagenham and Redbridge
Brighton & Hove Albion v Chelsea
Preston North End or Charlton Athletic v Wycombe Wanderers
Exeter City v Nottingham Forest
Coventry City v Ipswich Town
Blackburn Rovers v Wolverhampton Wanderers
Mansfield Town or Wigan Athletic v Fulham
Birmingham City v Newcastle United
Plymouth Argyle v Liverpool
Everton v Bournemouth
Aston Villa v Tottenham Hotspur
Southampton v Burnley
Leyton Orient or Derby County v Manchester City
Doncaster Rovers v Crystal Palace
Stoke City v Cardiff City