Marko Arnautovic came off the bench to score the winning goal as Inter Milan defeated Atletico Madrid 1-0 at the San Siro in the first leg of their Champions League last-16 tie.
The substitute fired home on the rebound with 11 minutes to play after Lautaro Martinez had been denied when racing through on goal by goalkeeper Jan Oblak, squeezing it inside the near post as Samuel Lino tried gallantly to clear from the goal line.
Earlier, Arnautovic and Martinez had wasted the two best chances of the game for the hosts, failing to find the target from good positions, as Diego Simeone’s side threatened to make it a frustrating night for the Serie A leaders.
For the visitors, Alvaro Morata headed wide from six yards out in the final minutes after getting on the end of Angel Correa’s deep cross.
Elsewhere, PSV Eindhoven came from behind to claim a 1-1 draw in their last-16 first leg against Borussia Dortmund.
Former PSV forward Donyell Malen scored after 24 minutes with a shot that deflected in at the near post beyond goalkeeper Walter Benitez.
But the Bundesliga side were denied the chance to take a one-goal advantage back to Germany when Luuk de Jong levelled from the penalty spot 11 minutes after the break.