Scientists have discovered how to switch off a key ‘pain gene’, dramatically raising hopes of a long-term treatment to relieve the agony of serious illness for millions.
The revolutionary technique alters a patient’s DNA, silencing a gene that transmits pain signals up the spine.
Preliminary studies on mice have already proven successful and US researchers plan to start human trials next year, potentially offering terminally-ill patients and those with chronic conditions the prospect of pain-free care.
The treatment, devised by start-up firm Navega Therapeutics in San Diego, California, could be approved for use in five years’ time, the founders told The Mail on Sunday.
People suffering from serious long-term pain – called chronic pain – are often put on opioid-based painkillers, causing an epidemic of addiction. By contrast, said Navega co-founder Fernando Aleman, ‘a major advantage of our approach is it’s not addictive’.
Their method uses the new high-precision gene-editing technique called CRISPR, which so far has mainly been used to combat rare hereditary diseases.
CRISPR utilises molecules that can be programmed to find a nominated ‘target’ gene. With each human cell containing around 25,000 genes, it has been compared to being able to find a needle in a haystack. A special protein then cuts out and replaces the defective target gene with a normal gene. Last month, researchers announced they had managed to reverse a patient’s sickle cell anaemia using this method.
Navega is using a slightly different CRISPR technique called ‘epi-genome editing’ which silences rather than replaces the gene. Co-founder Ana Moreno explained: ‘You can either activate or repress a gene of interest, without creating permanent changes. So we can repress the gene that’s known to cause sensitivity to pain.
‘We are really excited because we have seen, in three different pain models [ie. trials with mice], a decrease in overall pain.’
The mice were administered chemotherapy, which commonly causes pain in cancer patients. Dr Moreno continued: ‘One of the main reasons why cancer patients stop lifesaving chemotherapy, is they are in a lot of pain from it.
‘The higher the dose of chemotherapy, the more likely it is a patient will survive. But the higher the dose, the higher the likelihood they will suffer chronic pain.’
Cancer patients are often given morphine to mask their pain, but this can leave them so tired they can barely function.
So suppressing this ‘pain gene’ – called SCN9A – could be used as an alternative to morphine, helping cancer patients stay on chemotherapy longer and enabling them to live their final months more fully. Navega’s method involves placing the CRISPR-editing tool inside particles of a harmless virus, which acts like a Trojan horse.
These virus particles are injected into the spine, much like an epidural, after which they ‘infect’ neuron cells. Once inside a cell, the CRISPR tool is released and gets to work silencing the pain gene.
Dr Aleman admitted: ‘So far, we cannot ablate pain completely with our technology, in mice at least.
‘If you want to switch the pain off completely, you need to reach 100 per cent of the [neuron] cells you are trying to target.’
But it is possible to vary the amount of pain reduction depending on the dose administered – much like a standard painkilling drug.
Unlike conventional drugs, the effects won’t wear off quickly.
The effect may last ‘six months to a year’ in humans, said Dr Aleman, although he conceded they do not know yet. It will diminish as neurons get naturally replaced with cells that have not undergone gene suppression.
Geneticist Fyodor Urnov, a professor at University of California, Berkeley, welcomed Navega’s work, saying: ‘In the US, 70,000 people a year die of overdoses from painkilling narcotics. So having a non-narcotic way to address cancer pain would be a huge benefit.’
But he warned there could be a dark side – using CRISPR to engineer ‘a caste of genome-edited humans’ impervious to pain – a sinister possibility already raised by Russian President Vladimir Putin.
He told a meeting of the World Festival of Youth in Sochi in 2017 that while genetic engineering would ‘open up incredible opportunities’ in medicine, it could also be used to create individuals ‘who can fight without fear or pain’, a prospect which ‘may be more terrifying than a nuclear bomb’.