Parts of the Accra Academy School near Kaneshie has been engulfed in fire.
The fire started at Alema Hall, is reported to have started around 8:30 pm.
Two fire tenders have responded to the distress call and fire personnel are battling the fire.
All the students have been evacuated from the hall.
Two weeks ago, fire swept through the same Alema and Halm Addo Halls.
It is unclear what triggered the latest incident.