A Tipper truck with registration number, NR-153-20 has crushed a five-year-old pupil and her 10-month-old sibling to death at Kalpohin Estates in Tamale.
The incident reportedly occurred on Friday morning.
The two were being sent to school on a motorcycle by their aunt when the accident occurred.
According to eyewitnesses, a bicycle rider suddenly crossed their motorbike.
However, when she applied brakes, the children fell off the motorcycle and the truck which was following them smashed the kids, killing them instantly.
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The police have commenced investigations into the accident.